Ontology highlight
ABSTRACT:
SUBMITTER: Hite RK
PROVIDER: S-EPMC5513477 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Nature 20161214 7635
The precise control of an ion channel gate by environmental stimuli is crucial for the fulfilment of its biological role. The gate in Slo1 K<sup>+</sup> channels is regulated by two separate stimuli, intracellular Ca<sup>2+</sup> concentration and membrane voltage. Slo1 is thus central to understanding the relationship between intracellular Ca<sup>2+</sup> and membrane excitability. Here we present the Slo1 structure from Aplysia californica in the absence of Ca<sup>2+</sup> and compare it with ...[more]