Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC8628578 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Li Baobin B Rietmeijer Robert A RA Brohawn Stephen G SG
Nature 20200930 7829
TASK2 (also known as KCNK5) channels generate pH-gated leak-type K<sup>+</sup> currents to control cellular electrical excitability<sup>1-3</sup>. TASK2 is involved in the regulation of breathing by chemosensory neurons of the retrotrapezoid nucleus in the brainstem<sup>4-6</sup> and pH homeostasis by kidney proximal tubule cells<sup>7,8</sup>. These roles depend on channel activation by intracellular and extracellular alkalization<sup>3,8,9</sup>, but the mechanistic basis for TASK2 gating by p ...[more]