Ontology highlight
ABSTRACT:
SUBMITTER: Young FI
PROVIDER: S-EPMC5514752 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Young Fraser I FI Keruzore Marc M Nan Xinsheng X Gennet Nicole N Bellefroid Eric J EJ Li Meng M
Proceedings of the National Academy of Sciences of the United States of America 20170627 28
The mechanisms that determine whether a neural progenitor cell (NPC) reenters the cell cycle or exits and differentiates are pivotal for generating cells in the correct numbers and diverse types, and thus dictate proper brain development. Combining gain-of-function and loss-of-function approaches in an embryonic stem cell-derived cortical differentiation model, we report that doublesex- and mab-3-related transcription factor a2 (Dmrta2, also known as Dmrt5) plays an important role in maintaining ...[more]