Ontology highlight
ABSTRACT:
SUBMITTER: Huang C
PROVIDER: S-EPMC5514901 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Oncotarget 20170601 23
Factor Xa (FXa) plays a significant role in the blood coagulation cascade and is a promising target for anticoagulation drugs. Three oral FXa inhibitors have been approved by FDA for treating thrombotic diseases. In this study, 43 novel compounds were synthesized anthranilamide-based FXa inhibitors aiming to ameliorate the toxicity of traditional FXa inhibitors in clinic. The data indicated that the compounds 6a, 6a-b, 6a-e, 6k, 6k-a and 6k-b showed remarkable FXa inhibitory activity and excelle ...[more]