Ontology highlight
ABSTRACT:
SUBMITTER: Irazoqui JE
PROVIDER: S-EPMC551493 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Irazoqui Javier E JE Howell Audrey S AS Theesfeld Chandra L CL Lew Daniel J DJ
Molecular biology of the cell 20041222 3
In animal and fungal cells, the monomeric GTPase Cdc42p is a key regulator of cell polarity that itself exhibits a polarized distribution in asymmetric cells. Previous work showed that in budding yeast, Cdc42p polarization is unaffected by depolymerization of the actin cytoskeleton (Ayscough et al., J. Cell Biol. 137, 399-416, 1997). Surprisingly, we now report that unlike complete actin depolymerization, partial actin depolymerization leads to the dispersal of Cdc42p from the polarization site ...[more]