Ontology highlight
ABSTRACT:
SUBMITTER: Piccolo V
PROVIDER: S-EPMC5524187 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Piccolo Viviana V Curina Alessia A Genua Marco M Ghisletti Serena S Simonatto Marta M Sabò Arianna A Amati Bruno B Ostuni Renato R Natoli Gioacchino G
Nature immunology 20170313 5
Stimulation of macrophages with interferon-γ (IFN-γ) and interleukin 4 (IL-4) triggers distinct and opposing activation programs. During mixed infections or cancer, macrophages are often exposed to both cytokines, but how these two programs influence each other remains unclear. We found that IFN-γ and IL-4 mutually inhibited the epigenomic and transcriptional changes induced by each cytokine alone. Computational and functional analyses revealed the genomic bases for gene-specific cross-repressio ...[more]