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Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.

ABSTRACT: There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by an enzymatic route, bearing a hydroxyl group that can be further functionalized. Polymers with an average Mn of ?13 kDa can be synthesized without any post-polymerization deprotection reactions. Acylated polymers with fatty acid chain length of C₄, C₈, and C₁₈ (PGAB, PGAO, and PGAS, respectively) at different degrees of substitution were prepared. These modifications yield comb-like polymers that modulate the amphiphilic characteristics of PGA. This novel class of biocompatible polymers has been characterized through various techniques such as FT-IR, ¹H NMR, surface, thermal analysis, and their ability to self-assemble into colloidal structures was evaluated by using DLS. The highly tunable properties of PGA reported herein demonstrate a biodegradable polymer platform, ideal for engineering solid dispersions, nanoemulsions, or nanoparticles for healthcare applications. © 2016 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3267-3278.

SUBMITTER: Taresco V

PROVIDER: S-EPMC5516180 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.

Taresco Vincenzo V Suksiriworapong Jiraphong J Creasey Rhiannon R Burley Jonathan C JC Mantovani Giuseppe G Alexander Cameron C Treacher Kevin K Booth Jonathan J Garnett Martin C MC

Journal of polymer science. Part A, Polymer chemistry 20160708 20

There is an increasing need to develop bio-compatible polymers with an increased range of different physicochemical properties. Poly(glycerol-adipate) (PGA) is a biocompatible, biodegradable amphiphilic polyester routinely produced from divinyl adipate and unprotected glycerol by an enzymatic route, bearing a hydroxyl group that can be further functionalized. Polymers with an average Mn of ∼13 kDa can be synthesized without any post-polymerization deprotection reactions. Acylated polymers with f ...[more]

PMID: 28781423

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Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.

Publications

Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles.

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