Phosphoinositide 3-Kinase in Asthma: Novel Roles and Therapeutic Approaches.
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ABSTRACT:
SUBMITTER: Yoo EJ
PROVIDER: S-EPMC5516292 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Phosphoinositide 3-Kinase in Asthma: Novel Roles and Therapeutic Approaches.
Yoo Edwin J EJ Ojiaku Christie A CA Sunder Krishna K Panettieri Reynold A RA
American journal of respiratory cell and molecular biology 20170601 6
Asthma manifests as airway hyperresponsiveness and inflammation, including coughing, wheezing, and shortness of breath. Immune cells and airway structural cells orchestrate asthma pathophysiology, leading to mucus secretion, airway narrowing, and obstruction. Phosphoinositide 3-kinase, a lipid kinase, plays a crucial role in many of the cellular and molecular mechanisms driving asthma pathophysiology and represents an attractive therapeutic target. Here, we summarize the diverse roles of phospho ...[more]
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