Macrophage functions in lean and obese adipose tissue.
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ABSTRACT:
SUBMITTER: Thomas D
PROVIDER: S-EPMC5516622 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Macrophage functions in lean and obese adipose tissue.
Thomas Dylan D Apovian Caroline C
Metabolism: clinical and experimental 20170418
Interactions between macrophages and adipocytes influence both metabolism and inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic inflammation and insulin resistance. This paper reviews the various functions of macrophages in lean and obese adipose tissue and how obesity alters adipose tissue macrophage phenotypes. Metabolic disease and insulin resistance shift the balance between numerous pro- and anti-inflammatory regulators of macrophages and create a feed-forw ...[more]
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