Ontology highlight
ABSTRACT:
SUBMITTER: Qi Y
PROVIDER: S-EPMC5516899 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Qi Yuchen Y Zhang Xin-Jun XJ Renier Nicolas N Wu Zhuhao Z Atkin Talia T Sun Ziyi Z Ozair M Zeeshan MZ Tchieu Jason J Zimmer Bastian B Fattahi Faranak F Ganat Yosif Y Azevedo Ricardo R Zeltner Nadja N Brivanlou Ali H AH Karayiorgou Maria M Gogos Joseph J Tomishima Mark M Tessier-Lavigne Marc M Shi Song-Hai SH Studer Lorenz L
Nature biotechnology 20170123 2
Considerable progress has been made in converting human pluripotent stem cells (hPSCs) into functional neurons. However, the protracted timing of human neuron specification and functional maturation remains a key challenge that hampers the routine application of hPSC-derived lineages in disease modeling and regenerative medicine. Using a combinatorial small-molecule screen, we previously identified conditions to rapidly differentiate hPSCs into peripheral sensory neurons. Here we generalize the ...[more]