Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
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ABSTRACT:
SUBMITTER: Zillikens MC
PROVIDER: S-EPMC5517526 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
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Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Zillikens M Carola MC Demissie Serkalem S Hsu Yi-Hsiang YH Yerges-Armstrong Laura M LM Chou Wen-Chi WC Stolk Lisette L Livshits Gregory G Broer Linda L Johnson Toby T Koller Daniel L DL Kutalik Zoltán Z Luan Jian'an J Malkin Ida I Ried Janina S JS Smith Albert V AV Thorleifsson Gudmar G Vandenput Liesbeth L Hua Zhao Jing J Zhang Weihua W Aghdassi Ali A Åkesson Kristina K Amin Najaf N Baier Leslie J LJ Barroso Inês I Bennett David A DA Bertram Lars L Biffar Rainer R Bochud Murielle M Boehnke Michael M Borecki Ingrid B IB Buchman Aron S AS Byberg Liisa L Campbell Harry H Campos Obanda Natalia N Cauley Jane A JA Cawthon Peggy M PM Cederberg Henna H Chen Zhao Z Cho Nam H NH Jin Choi Hyung H Claussnitzer Melina M Collins Francis F Cummings Steven R SR De Jager Philip L PL Demuth Ilja I Dhonukshe-Rutten Rosalie A M RAM Diatchenko Luda L Eiriksdottir Gudny G Enneman Anke W AW Erdos Mike M Eriksson Johan G JG Eriksson Joel J Estrada Karol K Evans Daniel S DS Feitosa Mary F MF Fu Mao M Garcia Melissa M Gieger Christian C Girke Thomas T Glazer Nicole L NL Grallert Harald H Grewal Jagvir J Han Bok-Ghee BG Hanson Robert L RL Hayward Caroline C Hofman Albert A Hoffman Eric P EP Homuth Georg G Hsueh Wen-Chi WC Hubal Monica J MJ Hubbard Alan A Huffman Kim M KM Husted Lise B LB Illig Thomas T Ingelsson Erik E Ittermann Till T Jansson John-Olov JO Jordan Joanne M JM Jula Antti A Karlsson Magnus M Khaw Kay-Tee KT Kilpeläinen Tuomas O TO Klopp Norman N Kloth Jacqueline S L JSL Koistinen Heikki A HA Kraus William E WE Kritchevsky Stephen S Kuulasmaa Teemu T Kuusisto Johanna J Laakso Markku M Lahti Jari J Lang Thomas T Langdahl Bente L BL Launer Lenore J LJ Lee Jong-Young JY Lerch Markus M MM Lewis Joshua R JR Lind Lars L Lindgren Cecilia C Liu Yongmei Y Liu Tian T Liu Youfang Y Ljunggren Östen Ö Lorentzon Mattias M Luben Robert N RN Maixner William W McGuigan Fiona E FE Medina-Gomez Carolina C Meitinger Thomas T Melhus Håkan H Mellström Dan D Melov Simon S Michaëlsson Karl K Mitchell Braxton D BD Morris Andrew P AP Mosekilde Leif L Newman Anne A Nielson Carrie M CM O'Connell Jeffrey R JR Oostra Ben A BA Orwoll Eric S ES Palotie Aarno A Parker Stephen C J SCJ Peacock Munro M Perola Markus M Peters Annette A Polasek Ozren O Prince Richard L RL Räikkönen Katri K Ralston Stuart H SH Ripatti Samuli S Robbins John A JA Rotter Jerome I JI Rudan Igor I Salomaa Veikko V Satterfield Suzanne S Schadt Eric E EE Schipf Sabine S Scott Laura L Sehmi Joban J Shen Jian J Soo Shin Chan C Sigurdsson Gunnar G Smith Shad S Soranzo Nicole N Stančáková Alena A Steinhagen-Thiessen Elisabeth E Streeten Elizabeth A EA Styrkarsdottir Unnur U Swart Karin M A KMA Tan Sian-Tsung ST Tarnopolsky Mark A MA Thompson Patricia P Thomson Cynthia A CA Thorsteinsdottir Unnur U Tikkanen Emmi E Tranah Gregory J GJ Tuomilehto Jaakko J van Schoor Natasja M NM Verma Arjun A Vollenweider Peter P Völzke Henry H Wactawski-Wende Jean J Walker Mark M Weedon Michael N MN Welch Ryan R Wichmann H-Erich HE Widen Elisabeth E Williams Frances M K FMK Wilson James F JF Wright Nicole C NC Xie Weijia W Yu Lei L Zhou Yanhua Y Chambers John C JC Döring Angela A van Duijn Cornelia M CM Econs Michael J MJ Gudnason Vilmundur V Kooner Jaspal S JS Psaty Bruce M BM Spector Timothy D TD Stefansson Kari K Rivadeneira Fernando F Uitterlinden André G AG Wareham Nicholas J NJ Ossowski Vicky V Waterworth Dawn D Loos Ruth J F RJF Karasik David D Harris Tamara B TB Ohlsson Claes C Kiel Douglas P DP
Nature communications 20170719 1
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide ( ...[more]
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