Dataset Information

Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness.

ABSTRACT: Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index (AI _r ) can be more conveniently measured compared with carotid-femoral pulse wave velocity (cfPWV). However, the performance of AI _r in assessing arterial stiffness is limited. This study proposes a novel index AI _rd , a combination of AI _r and diastolic augmentation index (AI _d ) with a weight ?, to achieve better performance over AI _r in assessing arterial stiffness. 120 subjects (43?±?21 years old) were enrolled. The best-fit ? is determined by the best correlation coefficient between AI _rd and cfPWV. The performance of the method was tested using the 12-fold cross validation method. AI _rd (r?=?0.68, P?r (r?=?0.61, P?d (r?=?-0.17, P?=?0.06), the central augmentation index (AI _c ) (r?=?0.61, P?c normalized for heart rate of 75?bpm (r?=?0.65, P?r (age, P?rd has fewer confounding factors (age, P?rd derives performance improvement in assessing arterial stiffness, with a stronger correlation with cfPWV and fewer confounding factors.

SUBMITTER: Yao Y

PROVIDER: S-EPMC5517606 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness.

Yao Yang Y Hao Liling L Xu Lisheng L Zhang Yahui Y Qi Lin L Sun Yingxian Y Yang Benqiang B van de Vosse Frans N FN Yao Yudong Y

Scientific reports 20170719 1

Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index (AI r ) can be more conveniently measured compared with carotid-femoral pulse wave velocity (cfPWV). However, the performance of AI r in assessing arterial stiffness is limited. This study proposes a novel index AI rd , a combination of AI r and diastolic augmentation index (AI d ) with a weight α, to achieve better performance over AI r< ...[more]

PMID: 28724946

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Project description:PurposeThe study is aimed at identifying echocardiographic and circulating biomarkers as well as hemodynamic indices of embolic stroke of undetermined etiology (ESUS) in patients aged <65.MethodsWe prospectively investigated 520 patients with confirmed ischemic stroke and selected those 65 patients who were diagnosed with ESUS (age 54 (47-58) years, 42% male). An additional 36 without stroke but with a similar risk profile were included as a control group (age 53 (47-58) years, 61% male). All patients underwent echocardiography, noninvasive assessment of hemodynamic parameters using a SphygmoCor tonometer (AtCor Med., Australia), and measurements of selected biomarkers.ResultsESUS patients and controls were well matched for baseline characteristics including blood pressure and left ventricular ejection fraction (LVEF). Compared to controls, patients with ESUS had lower mean early diastolic (E') and systolic (S') mitral annular velocities and a higher ratio of the peak velocity of early diastolic transmitral flow to the peak velocity of early diastolic mitral annular motion (all p < 0.01). The peak velocity flow in the late diastole (A wave) value and LV mass indexed to the body surface area (LVMI) (g/m2) were higher in the ESUS group than in the control group (both p < 0.01). The isovolumetric relaxation time (IVRT) was longer and the mean left atrial volume index (LAVI) was higher in ESUS patients compared to the control group. Parameters of arterial stiffness such as augmentation pressure, augmentation index, and augmentation index adjusted to a heart rate of 75 bpm (AIx75) were higher in ESUS patients compared to controls (p < 0.05). Patients in the ESUS group had higher levels of asymmetric dimethylarginine, interleukin 6, and N-terminal probrain natriuretic peptide (NT-proBNP, all p < 0.05) than those in the control group. In multivariate analysis, the following factors were significantly associated with the presence of ESUS: AIx75 (odds ratio (OR) 1.095, 95% confidence interval (CI) 1.004-1.194; p = 0.04), IVRT (OR 1.045, 95% CI: 1.009-1.082; p = 0.014), LAVI (OR 1.3, 95% CI: 1.099-1.537; p = 0.002), and NT-proBNP (OR 1.003, 95% CI: 1.001-1.005; p = 0.005).ConclusionsIncreased arterial stiffness and indices of diastolic dysfunction as well as a higher NT-proBNP level are significantly associated with ESUS. These parameters require further scrutiny over time to understand their impact on the development of symptomatic heart failure. The ClinicalTrials.gov identifier is NCT03377465.

Dataset Information

Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness.

Publications

Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness.

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