Dataset Information

Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness.

ABSTRACT: Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index (AI _r ) can be more conveniently measured compared with carotid-femoral pulse wave velocity (cfPWV). However, the performance of AI _r in assessing arterial stiffness is limited. This study proposes a novel index AI _rd , a combination of AI _r and diastolic augmentation index (AI _d ) with a weight α, to achieve better performance over AI _r in assessing arterial stiffness. 120 subjects (43 ± 21 years old) were enrolled. The best-fit α is determined by the best correlation coefficient between AI _rd and cfPWV. The performance of the method was tested using the 12-fold cross validation method. AI _rd (r = 0.68, P < 0.001) shows a stronger correlation with cfPWV and a narrower prediction interval than AI _r (r = 0.61, P < 0.001), AI _d (r = -0.17, P = 0.06), the central augmentation index (AI _c ) (r = 0.61, P < 0.001) or AI _c normalized for heart rate of 75 bpm (r = 0.65, P < 0.001). Compared with AI _r (age, P < 0.001; gender, P < 0.001; heart rate, P < 0.001; diastolic blood pressure, P < 0.001; weight, P = 0.001), AI _rd has fewer confounding factors (age, P < 0.001; gender, P < 0.001). In conclusion, AI _rd derives performance improvement in assessing arterial stiffness, with a stronger correlation with cfPWV and fewer confounding factors.

SUBMITTER: Yao Y

PROVIDER: S-EPMC5517606 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness.

Yao Yang Y Hao Liling L Xu Lisheng L Zhang Yahui Y Qi Lin L Sun Yingxian Y Yang Benqiang B van de Vosse Frans N FN Yao Yudong Y

Scientific reports 20170719 1

Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index (AI r ) can be more conveniently measured compared with carotid-femoral pulse wave velocity (cfPWV). However, the performance of AI r in assessing arterial stiffness is limited. This study proposes a novel index AI rd , a combination of AI r and diastolic augmentation index (AI d ) with a weight α, to achieve better performance over AI r< ...[more]

PMID: 28724946

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Project description:ObjectivesCardiovascular disease is a major cause of morbidity and mortality in Antiphospholipid syndrome (APS). Arterial stiffness (ArS) has emerged as a predictor of future cardiovascular events in the general population. We aimed to assess ArS in patients with thrombotic APS versus diabetes mellitus (DM) and healthy controls (HC) and identify predictors of increased ArS in APS.MethodsArS was evaluated by carotid-femoral pulse wave velocity (cfPWV) and augmentation index normalized to 75 beats/min (AIx@75) using the SphygmoCor device. Participants also underwent carotid/femoral ultrasound for atherosclerotic plaque detection. We used linear regression to compare ArS measures among groups and assess ArS determinants in the APS group.ResultsWe included 110 patients with APS (70.9% female, mean age 45.4 years), 110 DM patients and 110 HC, all age/sex matched. After adjustment for age, sex, cardiovascular risk factors and plaque presence, APS patients exhibited similar cfPWV [β = -0.142 (95% CI -0.514, 0.230), p = 0.454] but increased AIx@75 [β = 4.525 (95% CI 1.372, 7.677), p = 0.005] compared with HC and lower cfPWV (p < 0.001) but similar AIx@75 (p = 0.193) versus DM patients. In the APS group, cfPWV was independently associated with age [β = 0.056 (95% CI 0.034, 0.078), p < 0.001], mean arterial pressure (MAP) [β = 0.070 (95% CI 0.043, 0.097), p < 0.001], atherosclerotic femoral plaques [β = 0.732 (95% CI 0.053, 1.411), p = 0.035] and anti-β2-glycoprotein I IgM positivity [β = 0.696 (95% CI 0.201, 1.191), p = 0.006]. AIx@75 was associated with age [β = 0.334 (95% CI 0.117, 0.551), p = 0.003], female sex [β = 7.447 (95% CI 2.312, 12.581), p = 0.005] and MAP [β = 0.425 (95% CI 0.187, 0.663), p = 0.001].ConclusionAPS patients exhibit elevated AIx@75 vs HC and similar to DM patients, indicating enhanced arterial stiffening in APS. Given its prognostic value, ArS evaluation may help to improve cardiovascular risk stratification in APS.

Dataset Information

Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness.

Publications

Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness.

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