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Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies.

ABSTRACT: We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.

SUBMITTER: Cai H

PROVIDER: S-EPMC5518472 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies.

Cai Hui H Orwenyo Jared J Guenaga Javier J Giddens John J Toonstra Christian C Wyatt Richard T RT Wang Lai-Xi LX

Chemical communications (Cambridge, England) 20170503 39

We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide. ...[more]

PMID: 28466900

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