Ontology highlight
ABSTRACT:
SUBMITTER: Saunders KO
PROVIDER: S-EPMC5408352 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Cell reports 20170201 9
Induction of broadly neutralizing antibodies (bnAbs) that target HIV-1 envelope (Env) is a goal of HIV-1 vaccine development. A bnAb target is the Env third variable loop (V3)-glycan site. To determine whether immunization could induce antibodies to the V3-glycan bnAb binding site, we repetitively immunized macaques over a 4-year period with an Env expressing V3-high mannose glycans. Env immunizations elicited plasma antibodies that neutralized HIV-1 expressing only high-mannose glycans-a charac ...[more]