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Cytomegalovirus-Responsive CD8+ T Cells Expand After Solid Organ Transplantation in the Absence of CMV Disease.


ABSTRACT: Cytomegalovirus (CMV) is a major cause of morbidity and mortality in solid organ transplant recipients. Approximately 60% of adults are CMV seropositive, indicating previous exposure. Following resolution of the primary infection, CMV remains in a latent state. Reactivation is controlled by memory T cells in healthy individuals; transplant recipients have reduced memory T cell function due to chronic immunosuppressive therapies. In this study, CD8+ T cell responses to CMV polypeptides immediate-early-1 and pp65 were analyzed in 16 CMV-seropositive kidney and heart transplant recipients longitudinally pretransplantation and posttransplantation. All patients received standard of care maintenance immunosuppression, antiviral prophylaxis, and CMV viral load monitoring, with approximately half receiving T cell-depleting induction therapy. The frequency of CMV-responsive CD8+ T cells, defined by the production of effector molecules in response to CMV peptides, increased during the course of 1 year posttransplantation. The increase commenced after the completion of antiviral prophylaxis, and these T cells tended to be terminally differentiated effector cells. Based on this small cohort, these data suggest that even in the absence of disease, antigenic exposure may continually shape the CMV-responsive T cell population posttransplantation.

SUBMITTER: Higdon LE 

PROVIDER: S-EPMC5519416 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Cytomegalovirus-Responsive CD8<sup>+</sup> T Cells Expand After Solid Organ Transplantation in the Absence of CMV Disease.

Higdon L E LE   Trofe-Clark J J   Liu S S   Margulies K B KB   Sahoo M K MK   Blumberg E E   Pinsky B A BA   Maltzman J S JS  

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20170313 8


Cytomegalovirus (CMV) is a major cause of morbidity and mortality in solid organ transplant recipients. Approximately 60% of adults are CMV seropositive, indicating previous exposure. Following resolution of the primary infection, CMV remains in a latent state. Reactivation is controlled by memory T cells in healthy individuals; transplant recipients have reduced memory T cell function due to chronic immunosuppressive therapies. In this study, CD8<sup>+</sup> T cell responses to CMV polypeptides  ...[more]

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