Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC5520412 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Cellular & molecular immunology 20160502 7
Myeloid-derived suppressor cells (MDSCs) are well known for their capacity to suppress antitumor T-cell responses, but their effects on B-cell function and antibody production remain unclear. Here, we found that MDSCs that accumulated around the germinal center in the spleen of tumor-bearing mice co-located with B cells. In the presence of MDSCs, the antibody reaction to a surrogate antigen was significantly enhanced in mice, especially the immunoglobulin (Ig)A subtype. Co-culture with MDSCs pro ...[more]