Ontology highlight
ABSTRACT:
SUBMITTER: Wamsley JJ
PROVIDER: S-EPMC5520489 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Wamsley J J JJ Gary C C Biktasova A A Hajek M M Bellinger G G Virk R R Issaeva N N Yarbrough W G WG
Oncogenesis 20170410 4
Chemotherapy and radiation, the two most common cancer therapies, exert their anticancer effects by causing damage to cellular DNA. However, systemic treatment damages DNA not only in cancer, but also in healthy cells, resulting in the progression of serious side effects and limiting efficacy of the treatment. Interestingly, in response to DNA damage, p53 seems to play an opposite role in normal and in the majority of cancer cells-wild-type p53 mediates apoptosis in healthy tissues, attributing ...[more]