Ontology highlight
ABSTRACT:
SUBMITTER: Lu CC
PROVIDER: S-EPMC5374521 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lu Chia-Chen CC Lee Chi-Chieh CC Tseng Ching-Tzu CT Tarn Woan-Yuh WY
Scientific reports 20170331
Y14 is a core component of the exon junction complex (EJC), while it also exerts cellular functions independent of the EJC. Depletion of Y14 causes G2/M arrest, DNA damage and apoptosis. Here we show that knockdown of Y14 induces the expression of an alternative spliced isoform of p53, namely p53β, in human cells. Y14, in the context of the EJC, inhibited aberrant exon inclusion during the splicing of p53 pre-mRNA, and thus prevent p53β expression. The anti-cancer agent camptothecin specifically ...[more]