Ontology highlight
ABSTRACT:
SUBMITTER: Bruno PM
PROVIDER: S-EPMC5520548 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Bruno Peter M PM Liu Yunpeng Y Park Ga Young GY Murai Junko J Koch Catherine E CE Eisen Timothy J TJ Pritchard Justin R JR Pommier Yves Y Lippard Stephen J SJ Hemann Michael T MT
Nature medicine 20170227 4
Cisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the most widely used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in germ cell, breast and lung malignancies, oxaliplatin is instead used almost exclusively to treat colorectal and other gastrointestinal cancers. Here we utilize a unique, multi-platform genetic approach to study the mechanism of action of these clinically established platinum anti-cancer agents, as well as more recentl ...[more]