Ontology highlight
ABSTRACT:
SUBMITTER: Sapio RT
PROVIDER: S-EPMC5567254 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Sapio Russell T RT Nezdyur Anastasiya N AN Krevetski Matthew M Anikin Leonid L Manna Vincent J VJ Minkovsky Natalie N Pestov Dimitri G DG
Scientific reports 20170822 1
The p53-mediated nucleolar stress response associated with inhibition of ribosomal RNA transcription was previously shown to potentiate killing of tumor cells. Here, we asked whether targeting of ribosome biogenesis can be used as the basis for selective p53-dependent cytoprotection of nonmalignant cells. Temporary functional inactivation of the 60S ribosome assembly factor Bop1 in a 3T3 cell model markedly increased cell recovery after exposure to camptothecin or methotrexate. This was due, at ...[more]