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MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer.

ABSTRACT: Lung cancer is the major form of cancer resulting in cancer-related mortality around the world. MicroRNAs are endogenous small non-coding single-stranded RNAs, which can engage in the regulation of gene expression. In this study, miR-18a-5p significantly upregulated in non-small cell lung cancer (NSCLC) tissues and NSCLC cell lines, suggesting an oncogenic function in lung cancer. Additionally, miR-18a-5p can promote carcinogenesis by directly targeting interferon regulatory factor 2 (IRF2). Further experiments indicated that IRF2 can increase cell apoptosis, inhibit cell proliferation and migration ability. Our study demonstrates that miR-18a-5p promotes autophagy in NSCLC. Collectively, these results indicate that miR-18a-5p can not only promote NSCLC by suppressing IRF2, but also will be a promising target in the near future.

SUBMITTER: Liang C

PROVIDER: S-EPMC5520692 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer.

Liang Chen C Zhang Xing X Wang Hui-Min HM Liu Xiao-Min XM Zhang Xin-Ju XJ Zheng Bo B Qian Guang-Ren GR Ma Zhong-Liang ZL

Cell death & disease 20170504 5

Lung cancer is the major form of cancer resulting in cancer-related mortality around the world. MicroRNAs are endogenous small non-coding single-stranded RNAs, which can engage in the regulation of gene expression. In this study, miR-18a-5p significantly upregulated in non-small cell lung cancer (NSCLC) tissues and NSCLC cell lines, suggesting an oncogenic function in lung cancer. Additionally, miR-18a-5p can promote carcinogenesis by directly targeting interferon regulatory factor 2 (IRF2). Fur ...[more]

PMID: 28471447

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