Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.
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ABSTRACT:
SUBMITTER: Cai L
PROVIDER: S-EPMC5521188 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
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Regulating Stem Cell Secretome Using Injectable Hydrogels with In Situ Network Formation.
Cai Lei L Dewi Ruby E RE Goldstone Andrew B AB Cohen Jeffrey E JE Steele Amanda N AN Woo Y Joseph YJ Heilshorn Sarah C SC
Advanced healthcare materials 20161006 21
A family of shear-thinning hydrogels for injectable encapsulation and long-term delivery (SHIELD) has been designed and synthesized with controlled in situ stiffening properties to regulate the stem cell secretome. The authors demonstrate that SHIELD with an intermediate stiffness (200-400 Pa) could significantly promote the angiogenic potential of human adipose-derived stem cells. ...[more]
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