Ontology highlight
ABSTRACT:
SUBMITTER: Rossen NS
PROVIDER: S-EPMC7191221 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Rossen Ninna S NS Anandakumaran Priya N PN Zur Nieden Rafael R Lo Kahmun K Luo Wenjie W Park Christian C Huyan Chuqiao C Fu Qinyouen Q Song Ziwei Z Singh-Moon Rajinder P RP Chung Janice J Goldenberg Jennifer E JE Sampat Nirali N Harimoto Tetsuhiro T Bajakian Danielle R DR Gillette Brian M BM Sia Samuel K SK
iScience 20200412 5
Organoids are becoming widespread in drug-screening technologies but have been used sparingly for cell therapy as current approaches for producing self-organized cell clusters lack scalability or reproducibility in size and cellular organization. We introduce a method of using hydrogels as sacrificial scaffolds, which allow cells to form self-organized clusters followed by gentle release, resulting in highly reproducible multicellular structures on a large scale. We demonstrated this strategy fo ...[more]