Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders.
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ABSTRACT:
SUBMITTER: Mozzi A
PROVIDER: S-EPMC5522412 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders.
Mozzi Alessandra A Forni Diego D Cagliani Rachele R Pozzoli Uberto U Clerici Mario M Sironi Manuela M
Scientific reports 20170721 1
In addition to high intelligence, humans evolved specialized social-cognitive skills, which are specifically affected in children with autism spectrum disorder (ASD). Genes affected in ASD represent suitable candidates to study the evolution of human social cognition. We performed an evolutionary analysis on 68 genes associated to neurodevelopmental disorders; our data indicate that genetic diversity was shaped by distinct selective forces, including natural selection and introgression from arch ...[more]
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