Ontology highlight
ABSTRACT:
SUBMITTER: Lei J
PROVIDER: S-EPMC5522481 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Lei Jun J Rosenzweig Jason M JM Mishra Manoj K MK Alshehri Wael W Brancusi Flavia F McLane Mike M Almalki Ahmad A Bahabry Rudhab R Arif Hattan H Rozzah Rayyan R Alyousif Ghada G Shabi Yahya Y Alhehaily Nader N Zhong Wenyu W Facciabene Andrea A Kannan Sujatha S Kannan Rangaramanujam M RM Burd Irina I
Scientific reports 20170721 1
Preterm birth is a major risk factor for adverse neurological outcomes in ex-preterm children, including motor, cognitive, and behavioral disabilities. N-acetyl-L-cysteine therapy has been used in clinical studies; however, it requires doses that cause significant side effects. In this study, we explore the effect of low dose N-acetyl-L-cysteine therapy, delivered using a targeted, systemic, maternal, dendrimer nanoparticle (DNAC), in a mouse model of intrauterine inflammation. Our results demon ...[more]