Unknown

Dataset Information

0

Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury.


ABSTRACT: Preterm birth is a major risk factor for adverse neurological outcomes in ex-preterm children, including motor, cognitive, and behavioral disabilities. N-acetyl-L-cysteine therapy has been used in clinical studies; however, it requires doses that cause significant side effects. In this study, we explore the effect of low dose N-acetyl-L-cysteine therapy, delivered using a targeted, systemic, maternal, dendrimer nanoparticle (DNAC), in a mouse model of intrauterine inflammation. Our results demonstrated that intraperitoneal maternal DNAC administration significantly reduced the preterm birth rate and altered placental immune profile with decreased CD8+ T-cell infiltration. Furthermore, we demonstrated that DNAC improved neurobehavioral outcomes and reduced fetal neuroinflammation and long-term microglial activation in offspring. Our study is the first to provide evidence for the role of CD8+ T-cell in the maternal-fetal interface during inflammation and further support the efficacy of DNAC in preventing preterm birth and prematurity-related outcomes.

SUBMITTER: Lei J 

PROVIDER: S-EPMC5522481 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications


Preterm birth is a major risk factor for adverse neurological outcomes in ex-preterm children, including motor, cognitive, and behavioral disabilities. N-acetyl-L-cysteine therapy has been used in clinical studies; however, it requires doses that cause significant side effects. In this study, we explore the effect of low dose N-acetyl-L-cysteine therapy, delivered using a targeted, systemic, maternal, dendrimer nanoparticle (DNAC), in a mouse model of intrauterine inflammation. Our results demon  ...[more]

Similar Datasets

2023-08-03 | GSE202811 | GEO
| S-EPMC7655424 | biostudies-literature
2021-12-01 | GSE183698 | GEO
| S-EPMC7764185 | biostudies-literature
| S-EPMC6168615 | biostudies-literature
| S-EPMC5333966 | biostudies-literature
| S-EPMC6715541 | biostudies-literature
| S-EPMC6446074 | biostudies-literature
| S-EPMC3873106 | biostudies-literature
| S-EPMC7980401 | biostudies-literature