A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells.

ABSTRACT: The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during hematopoietic development are unclear. Using an irreversible lineage-tracing model, we identify a definitive hematopoietic stem cell (HSC) that supports long-term multilineage reconstitution upon transplantation into adult recipients but does not persist into adulthood in situ. These HSCs are fully multipotent, yet they display both higher lymphoid cell production and greater capacity to generate innate-like B and T lymphocytes as compared to coexisting fetal HSCs and adult HSCs. Thus, these developmentally restricted HSCs (drHSCs) define the origi

SUBMITTER: Beaudin AE 

PROVIDER: S-EPMC5524382 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature