Ontology highlight
ABSTRACT:
SUBMITTER: Tripp J
PROVIDER: S-EPMC5524692 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Tripp Joanna J Essl Christine C Iancu Cristina V CV Boles Eckhard E Choe Jun-Yong JY Oreb Mislav M
Scientific reports 20170724 1
Human GLUT5 is a fructose-specific transporter in the glucose transporter family (GLUT, SLC2 gene family). Its substrate-specificity and tissue-specific expression make it a promising target for treatment of diabetes, metabolic syndrome and cancer, but few GLUT5 inhibitors are known. To identify and characterize potential GLUT5 ligands, we developed a whole-cell system based on a yeast strain deficient in fructose uptake, in which GLUT5 transport activity is associated with cell growth in fructo ...[more]