Association of PPAR Alpha Intron 7 G/C, PPAR Gamma 2 Pro12Ala, and C161T Polymorphisms with Serum Fetuin-A Concentrations.

ABSTRACT:

Background

Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism.

Aims

We investigated whether PPARα intron 7 G2468/C and PPARγ2 Pro12Ala and PPARγ exon 6 C161T polymorphisms are associated with serum fetuin-A concentrations.

Patients and methods

The PPARα intron 7 G/C polymorphism was studied in cohort 1 (79 reference individuals, 165 postinfarction patients). The two PPARγ polymorphisms were investigated in cohort 2 (162 reference individuals, 165 postinfarction patients). Fetuin-A levels and PPAR polymorphisms were determined by radial immunodiffusion and polymerase chain reaction-restriction fragment length polymorphism techniques.

Results

The C allele variant of PPARα i

SUBMITTER: Markus B 

PROVIDER: S-EPMC5525087 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature