Dataset Information

Pro12Ala Polymorphism on the PPAR?2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial.

ABSTRACT: The objective of this study was to verify the influence of the Pro12Ala polymorphism of the PPAR?2 gene in response of a training program on the body composition. Sixty-nine previously inactive men and women (32.8 ± 8.2 years) were genotyped and underwent a 12-week aerobic (running/walking) training program (3-5 sessions, 40 - 60 min per session, and intensity between the aerobic and anaerobic threshold) (experimental group n = 53) or were part of the control group (n = 16). They were tested for aerobic capacity (ergospirometry), body composition (DXA), abdomen, waist and hip circumferences and nutritional assessment before and 48 h after the experimental protocol. Two-way repeated measures ANOVA test was used to verify possible differences in variables between the experimental vs. control groups or Pro/Pro vs. Pro/Ala groups, and the Chi-squared test was used to verify the distribution of responders and non-responders according to genotype (p < 0.05). Frequencies of 75.5% Pro/Pro (n = 40) and 24.5% Pro/Ala (n = 13) were found, without any occurrence of the recessive homozygote. Body fat reduction was initially confirmed compared to a control group which did not exercise (n = 16; 29.1 ± 8.8 years), so that the exercise group obtained a reduction of -1.3 kg vs. -0.3 kg in the control group (p = 0.03). When they were divided by genotype, there were significant changes in fat mass (-1.3 ± 2.1 kg; p = 0.00), lean mass (0.6 ± 1.5 kg; p = 0.02), fat percentage (-1.3 ± 1.6; p = 0.00), waist circumference (-2.2 ± 2.9 cm; p = 0.00), abdomen circumference (-3.3 ± 3.6 cm; p = 0.00) and hip circumference (-2.7 ± 2.7 cm; p = 0.00) for Pro/Pro genotypes; and fat mass (-1.1 ± 1.7 kg; p = 0.04), fat percentage (-0.9 ± 1.5; p = 0.04), abdomen circumference (-3.9 ± 3.5 cm; p = 0.00) and hip circumference (-1.8 ± 1.8 cm; p = 0.00) for Pro/Ala genotypes, without any group interaction differences. The Chi squared test revealed no differences in the distribution of responders or non-responders according to genotype. It is concluded that an aerobic training program promotes weight loss, but the Pro12Ala polymorphism in the PPAR?2 gene does not influence the variability of aerobic-induced exercise weight loss.

SUBMITTER: Cardoso GA

PROVIDER: S-EPMC7227424 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Pro12Ala Polymorphism on the PPARγ2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial.

Cardoso Glêbia Alexa GA Persuhn Darlene Camati DC Ribeiro Mateus Duarte MD de Sousa Bruno Rafael Virgínio BRV Sena Klécia de Farias KF de Almeida Antônio Eduardo Monteiro AEM Modesto-Filho João J da Silva Raquel Suelen Brito RSB Silva Alexandre Sérgio AS

Frontiers in physiology 20200508

The objective of this study was to verify the influence of the Pro12Ala polymorphism of the PPARγ2 gene in response of a training program on the body composition. Sixty-nine previously inactive men and women (32.8 ± 8.2 years) were genotyped and underwent a 12-week aerobic (running/walking) training program (3-5 sessions, 40 - 60 min per session, and intensity between the aerobic and anaerobic threshold) (experimental group n = 53) or were part of the control group (n = 16). They w ...[more]

PMID: 32457643

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Dataset Information

Pro12Ala Polymorphism on the PPAR?2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial.

Publications

Pro12Ala Polymorphism on the PPAR<sub>γ</sub>2 Gene and Weight Loss After Aerobic Training: A Randomized Controlled Trial.

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