Ontology highlight
ABSTRACT:
SUBMITTER: D'Aiuto L
PROVIDER: S-EPMC5525147 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
D'Aiuto Leonardo L Williamson Kelly K Dimitrion Peter P McNulty James J Brown Carla E CE Dokuburra Chanti Babu CB Nielsen Alexander J AJ Lin Wen Jing WJ Piazza Paolo P Schurdak Mark E ME Wood Joel J Yolken Robert H RH Kinchington Paul R PR Bloom David C DC Nimgaonkar Vishwajit L VL
Antiviral research 20170323
Acyclovir (ACV) and its derivatives have been highly effective for treating recurrent, lytic infections with Herpes Simplex Virus, type 1 (HSV-1), but searches for additional antiviral drugs are motivated by recent reports of resistance to ACV, particularly among immunocompromised patients. In addition, the relative neurotoxicity of ACV and its inability to prevent neurological sequelae among HSV-1 encephalitis survivors compel searches for new drugs to treat HSV-1 infections of the central nerv ...[more]