Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by ?4?7 integrin.
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ABSTRACT:
SUBMITTER: Chand S
PROVIDER: S-EPMC5526109 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
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Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by α4β7 integrin.
Chand Subhash S Messina Emily L EL AlSalmi Wadad W Ananthaswamy Neeti N Gao Guofen G Uritskiy Gherman G Padilla-Sanchez Victor V Mahalingam Marthandan M Peachman Kristina K KK Robb Merlin L ML Rao Mangala M Rao Venigalla B VB
Virology 20170531
The α4ß7 integrin present on host cells recognizes the V1V2 domain of the HIV-1 envelope protein. This interaction might be involved in virus transmission. Administration of α4ß7-specific antibodies inhibit acquisition of SIV in a macaque challenge model. But the molecular details of V1V2: α4ß7 interaction are unknown and its importance in HIV-1 infection remains controversial. Our biochemical and mutational analyses show that glycosylation is a key modulator of V1V2 conformation and binding to ...[more]
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