Ontology highlight
ABSTRACT:
SUBMITTER: Dal Cortivo G
PROVIDER: S-EPMC6803640 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Dal Cortivo Giuditta G Marino Valerio V Iacobucci Claudio C Vallone Rosario R Arlt Christian C Rehkamp Anne A Sinz Andrea A Dell'Orco Daniele D
Scientific reports 20191021 1
Calcium- and Integrin-Binding protein 2 (CIB2) is a small and ubiquitously expressed protein with largely unknown biological function but ascertained role in hearing physiology and disease. Recent studies found that CIB2 binds Ca<sup>2+</sup> with moderate affinity and dimerizes under conditions mimicking the physiological ones. Here we provided new lines of evidence on CIB2 oligomeric state and the mechanism of interaction with the α7B integrin target. Based on a combination of native mass spec ...[more]