Phototactic guidance of a tissue-engineered soft-robotic ray.
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ABSTRACT:
SUBMITTER: Park SJ
PROVIDER: S-EPMC5526330 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Phototactic guidance of a tissue-engineered soft-robotic ray.
Park Sung-Jin SJ Gazzola Mattia M Park Kyung Soo KS Park Shirley S Di Santo Valentina V Blevins Erin L EL Lind Johan U JU Campbell Patrick H PH Dauth Stephanie S Capulli Andrew K AK Pasqualini Francesco S FS Ahn Seungkuk S Cho Alexander A Yuan Hongyan H Maoz Ben M BM Vijaykumar Ragu R Choi Jeong-Woo JW Deisseroth Karl K Lauder George V GV Mahadevan L L Parker Kevin Kit KK
Science (New York, N.Y.) 20160701 6295
Inspired by the relatively simple morphological blueprint provided by batoid fish such as stingrays and skates, we created a biohybrid system that enables an artificial animal--a tissue-engineered ray--to swim and phototactically follow a light cue. By patterning dissociated rat cardiomyocytes on an elastomeric body enclosing a microfabricated gold skeleton, we replicated fish morphology at 1/10 scale and captured basic fin deflection patterns of batoid fish. Optogenetics allows for phototactic ...[more]
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