Wnt/?-catenin promotes gastric fundus specification in mice and humans.
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ABSTRACT:
SUBMITTER: McCracken KW
PROVIDER: S-EPMC5526592 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Wnt/β-catenin promotes gastric fundus specification in mice and humans.
McCracken Kyle W KW Aihara Eitaro E Martin Baptiste B Crawford Calyn M CM Broda Taylor T Treguier Julie J Zhang Xinghao X Shannon John M JM Montrose Marshall H MH Wells James M JM
Nature 20170104 7636
Despite the global prevalence of gastric disease, there are few adequate models in which to study the fundus epithelium of the human stomach. We differentiated human pluripotent stem cells (hPSCs) into gastric organoids containing fundic epithelium by first identifying and then recapitulating key events in embryonic fundus development. We found that disruption of Wnt/β-catenin signalling in mouse embryos led to conversion of fundic to antral epithelium, and that β-catenin activation in hPSC-deri ...[more]
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