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30-Second bound and pore water concentration mapping of cortical bone using 2D UTE with optimized half-pulses.

ABSTRACT: MRI of cortical bone has the potential to offer new information about fracture risk. Current methods are typically performed with 3D acquisitions, which suffer from long scan times and are generally limited to extremities. This work proposes using 2D UTE with half pulses for quantitatively mapping bound and pore water in cortical bone.Half-pulse 2D UTE methods were implemented on a 3T Philips Achieva scanner using an optimized slice-select gradient waveform, with preparation pulses to selectively image bound or pore water. The 2D methods were quantitatively compared with previously implemented 3D methods in the tibia in five volunteers.The mean difference between bound and pore water concentration acquired from 3D and 2D sequences was 0.6 and 0.9 mol 1 H/Lbone (3 and 12%, respectively). While 2D pore water methods tended to slightly overestimate concentrations relative to 3D methods, differences were less than scan-rescan uncertainty and expected differences between healthy and fracture-prone bones.Quantitative bound and pore water concentration mapping in cortical bone can be accelerated by 2 orders of magnitude using 2D protocols with optimized half-pulse excitation. Magn Reson Med 77:945-950, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Manhard MK

PROVIDER: S-EPMC5526671 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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30-Second bound and pore water concentration mapping of cortical bone using 2D UTE with optimized half-pulses.

Manhard Mary Kate MK Harkins Kevin D KD Gochberg Daniel F DF Nyman Jeffry S JS Does Mark D MD

Magnetic resonance in medicine 20170116 3

<h4>Purpose</h4>MRI of cortical bone has the potential to offer new information about fracture risk. Current methods are typically performed with 3D acquisitions, which suffer from long scan times and are generally limited to extremities. This work proposes using 2D UTE with half pulses for quantitatively mapping bound and pore water in cortical bone.<h4>Methods</h4>Half-pulse 2D UTE methods were implemented on a 3T Philips Achieva scanner using an optimized slice-select gradient waveform, with ...[more]

PMID: 28090655

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Project description:The purpose of this study was to investigate the effect of excitation, fat saturation, long T2 saturation, and adiabatic inversion pulses on ultrashort echo time (UTE) imaging with bicomponent analysis of bound and free water in cortical bone for potential applications in osteoporosis.Six bovine cortical bones and six human tibial midshaft samples were harvested for this study. Each bone sample was imaged with eight sequences using 2D UTE imaging at 3T with half and hard excitation pulses, without and with fat saturation, long T2 saturation, and adiabatic inversion recovery (IR) preparation pulses. Single- and bicomponent signal models were utilized to calculate the T2(*)s and/or relative fractions of short and long T2(*)s.For all bone samples UTE T2(*) signal decay showed bicomponent behavior. A higher short T2(*) fraction was observed on UTE images with hard pulse excitation compared with half pulse excitation (75.6% vs 68.8% in bovine bone, 79.9% vs 73.2% in human bone). Fat saturation pulses slightly reduced the short T2(*) fraction relative to regular UTE sequences (5.0% and 2.0% reduction, respectively, with half and hard excitation pulses for bovine bone, 6.3% and 8.2% reduction, respectively, with half and hard excitation pulses for human bone). Long T2 saturation pulses significantly reduced the long T2(*) fraction relative to regular UTE sequence (18.9% and 17.2% reduction, respectively, with half and hard excitation pulses for bovine bone, 26.4% and 27.7% reduction, respectively, with half and hard excitation pulses for human bone). With IR-UTE preparation the long T2(*) components were significantly reduced relative to regular UTE sequence (75.3% and 66.4% reduction, respectively, with half and hard excitation pulses for bovine bone, 87.7% and 90.3% reduction, respectively, with half and hard excitation pulses for human bone).Bound and free water T2(*)s and relative fractions can be assessed using UTE bicomponent analysis. Long T2(*) components are affected more by long T2 saturation and IR pulses, and short T2(*) components are affected more by fat saturation pulses.

Dataset Information

30-Second bound and pore water concentration mapping of cortical bone using 2D UTE with optimized half-pulses.

Publications

30-Second bound and pore water concentration mapping of cortical bone using 2D UTE with optimized half-pulses.

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