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Radiofrequency phase encoded half-pulses in simultaneous multislice ultrashort echo time imaging.

ABSTRACT: PURPOSE:To describe a simultaneous multislice (SMS) ultrashort echo time (UTE) imaging method using radiofrequency phase encoded half-pulses in combination with power independent of number of slices (PINS) inversion recovery (IR) pulses to generate multiple-slice images with short T2 * contrasts in less than 3 min with close to an eightfold acceleration compared with a standard 2D approach. THEORY AND METHODS:Radiofrequency phase encoding is applied in an SMS (NSMS = 4) excitation scheme using "sinc" half-pulses. With the use of coil sensitivity encoding (SENSE) and controlled aliasing in parallel imaging (CAIPI) in combination with a gradient echo 2D spiral readout trajectory and IR PINS pulses for contrast enhancement a fast UTE sequence is developed. Images are obtained using a model-based reconstruction method. Sequence details and performance tests on phantoms as well as the heads of healthy volunteers at 3T are presented. RESULTS:An SMS UTE sequence with an undersampling factor of 4 is developed using radiofrequency phase encoded half-pulses and PINS IR pulses which enables the acquisition of 8 slices at 0.862 mm2 resolution in less than 3-min scan time. UTE images of the head are obtained showing highlighted signal of cortical bone. Image quality and T2 contrast are comparable to the one obtained by corresponding single slice acquisitions with only minor deviations. CONCLUSIONS:The method combining radiofrequency phase encoded SMS half-pulses and PINS IR pulses presents a suitable approach to SMS UTE imaging. The usage of coil sensitivity information and increased sampling density by means of interleaved slice group acquisitions allows to reduce the total scan time by a factor close to 8.

SUBMITTER: Rettenmeier C

PROVIDER: S-EPMC6435423 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Project description:PurposeSpin-echo functional MRI (SE-fMRI) has the potential to improve spatial specificity when compared with gradient-echo fMRI. However, high spatiotemporal resolution SE-fMRI with large slice-coverage is challenging as SE-fMRI requires a long echo time to generate blood oxygenation level-dependent (BOLD) contrast, leading to long repetition times. The aim of this work is to develop an acquisition method that enhances the slice-coverage of SE-fMRI at high spatiotemporal resolution.Theory and methodsAn acquisition scheme was developed entitled multisection excitation by simultaneous spin-echo interleaving (MESSI) with complex-encoded generalized slice dithered enhanced resolution (cgSlider). MESSI uses the dead-time during the long echo time by interleaving the excitation and readout of 2 slices to enable 2× slice-acceleration, while cgSlider uses the stable temporal background phase in SE-fMRI to encode/decode 2 adjacent slices simultaneously with a "phase-constrained" reconstruction method. The proposed cgSlider-MESSI was also combined with simultaneous multislice (SMS) to achieve further slice-acceleration. This combined approach was used to achieve 1.5-mm isotropic whole-brain SE-fMRI with a temporal resolution of 1.5 s and was evaluated using sensory stimulation and breath-hold tasks at 3T.ResultsCompared with conventional SE-SMS, cgSlider-MESSI-SMS provides 4-fold increase in slice-coverage for the same repetition time, with comparable temporal signal-to-noise ratio. Corresponding fMRI activation from cgSlider-MESSI-SMS for both fMRI tasks were consistent with those from conventional SE-SMS. Overall, cgSlider-MESSI-SMS achieved a 32× encoding-acceleration by combining Rinplane × MB × cgSlider × MESSI = 4 × 2 × 2 × 2.ConclusionHigh-quality, high-resolution whole-brain SE-fMRI was acquired at a short repetition time using cgSlider-MESSI-SMS. This method should be beneficial for high spatiotemporal resolution SE-fMRI studies requiring whole-brain coverage.

Project description:BackgroundComputed tomography (CT) and spirometry are the current standard methods for assessing lung anatomy and pulmonary ventilation, respectively. However, CT provides limited ventilation information and spirometry only provides global measures of lung ventilation. Thus, a method that can enable simultaneous examination of lung anatomy and ventilation is of clinical interest.PurposeTo develop and test a 4D respiratory-resolved sparse lung MRI (XD-UTE: eXtra-Dimensional Ultrashort TE imaging) approach for simultaneous evaluation of lung anatomy and pulmonary ventilation.Study typeProspective.PopulationIn all, 23 subjects (11 volunteers and 12 patients, mean age = 63.6 ± 8.4).Field strength/sequence3T MR; a prototype 3D golden-angle radial UTE sequence, a Cartesian breath-hold volumetric-interpolated examination (BH-VIBE) sequence.AssessmentAll subjects were scanned using the 3D golden-angle radial UTE sequence during normal breathing. Ten subjects underwent an additional scan during alternating normal and deep breathing. Respiratory-motion-resolved sparse reconstruction was performed for all the acquired data to generate dynamic normal-breathing or deep-breathing image series. For comparison, BH-VIBE was performed in 12 subjects. Lung images were visually scored by three experienced chest radiologists and were analyzed by two observers who segmented the left and right lung to derive ventilation parameters in comparison with spirometry.Statistical testsNonparametric paired two-tailed Wilcoxon signed-rank test; intraclass correlation coefficient, Pearson correlation coefficient.ResultsXD-UTE achieved significantly improved image quality compared both with Cartesian BH-VIBE and radial reconstruction without motion compensation (P < 0.05). The global ventilation parameters (a sum of the left and right lung measures) were in good correlation with spirometry in the same subjects (correlation coefficient = 0.724). There were excellent correlations between the results obtained by two observers (intraclass correlation coefficient ranged from 0.8855-0.9995).Data conclusionSimultaneous evaluation of lung anatomy and ventilation using XD-UTE is demonstrated, which have shown good potential for improved diagnosis and management of patients with heterogeneous lung diseases.Level of evidence2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:411-422.

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Radiofrequency phase encoded half-pulses in simultaneous multislice ultrashort echo time imaging.

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