Ontology highlight
ABSTRACT:
SUBMITTER: King IL
PROVIDER: S-EPMC5526748 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
King I L IL Mohrs K K Meli A P AP Downey J J Lanthier P P Tzelepis F F Fritz J H JH Tumanov A V AV Divangahi M M Leadbetter E A EA Mohrs M M
Mucosal immunology 20170125 5
Homeostasis is a fundamental principle of biological systems. A paradigm of immune homeostasis is the remarkably constant number of naive T and B lymphocytes in the body that continuously circulate through the secondary lymphoid organs to maximize immune surveillance. Whether the dynamics and distribution of the systemic naive lymphocyte pool is affected following organ-specific infection is not known. Here we show that, following infection of mice with an enteric helminth, naive T and B lymphoc ...[more]