Ontology highlight
ABSTRACT:
SUBMITTER: Khoshgoo N
PROVIDER: S-EPMC5526907 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20170725 1
miR-200b plays a role in epithelial-to-mesenchymal transition (EMT) in cancer. We recently reported abnormal expression of miR-200b in the context of human pulmonary hypoplasia in congenital diaphragmatic hernia (CDH). Smaller lung size, a lower number of airway generations, and a thicker mesenchyme characterize pulmonary hypoplasia in CDH. The aim of this study was to define the role of miR-200b during lung development. Here we show that miR-200b<sup>-/-</sup> mice have abnormal lung function d ...[more]