Ontology highlight
ABSTRACT:
SUBMITTER: Lai JC
PROVIDER: S-EPMC5527020 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20170725 1
Disease diagnosis typically requires to determine concentration of multiple biomarkers in patient serums. Here, a novel method for multiplex immunoassays is proposed and the feasibility is demonstrated. The method utilizes the differential affinity between aptamers and multiple analytes for multiplex immunoassays. During the selection, aptamers capable of binding to multiple analytes with different affinities are screened from a random oligonucleotide library using the MARAS procedure with diffe ...[more]