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Circulation of blaKPC-3-Carrying IncX3 Plasmids among Citrobacter freundii Isolates in an Italian Hospital.

ABSTRACT: Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. blaKPC-3-carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes.

SUBMITTER: Venditti C

PROVIDER: S-EPMC5527586 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Circulation of blaKPC-3-Carrying IncX3 Plasmids among Citrobacter freundii Isolates in an Italian Hospital.

Venditti Carolina C Fortini Daniela D Villa Laura L Vulcano Antonella A D'Arezzo Silvia S Capone Alessandro A Petrosillo Nicola N Nisii Carla C Carattoli Alessandra A Di Caro Antonino A

Antimicrobial agents and chemotherapy 20170725 8

Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. blaKPC-3-carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possib ...[more]

PMID: 28559268

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