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Interplay among IncA and bla KPC-Carrying Plasmids in Citrobacter freundii.

ABSTRACT: We report two KPC-producing Citrobacter freundii isolates from unrelated patients. In one case, bla KPC-2 was harbored on a novel variant of a Tn4401 transposon of an IncN plasmid conjugated together with a coresident IncA plasmid, whereas in the other one, bla KPC-3 was on a Tn4401a transposon located on an IncX3-IncA self-conjugative plasmid fusion. The interplay among plasmids carrying bla KPC and the coresident IncA plasmids offers new information on plasmids coresident within clinically relevant enterobacteria.

SUBMITTER: Bitar I

PROVIDER: S-EPMC6496092 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Interplay among IncA and blaKPC-Carrying Plasmids in Citrobacter freundii.

Bitar Ibrahim I Caltagirone Mariasofia M Villa Laura L Mattioni Marchetti Vittoria V Nucleo Elisabetta E Sarti Mario M Migliavacca Roberta R Carattoli Alessandra A

Antimicrobial agents and chemotherapy 20190425 5

We report two KPC-producing Citrobacter freundii isolates from unrelated patients. In one case, blaKPC-2 was harbored on a novel variant of a Tn4401 transposon of an IncN plasmid conjugated together with a coresident IncA plasmid, whereas in the other one, blaKPC-3 was on a Tn4401a transposon located on an IncX3-IncA self-conjugative plasmid fusion. The interplay among plasmids carrying blaKPC and the coresident IncA plas ...[more]

PMID: 30858205

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