Ontology highlight
ABSTRACT:
SUBMITTER: Ose R
PROVIDER: S-EPMC5527873 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Ose Rui R Yanagawa Toshihide T Ikeda Shun S Ohara Osamu O Koga Hisashi H
Molecular oncology 20081106 1
Elevated expression of the protocadherin LKC (PCDH24) in HCT116 colon carcinoma cells has been shown to induce contact inhibition, thereby completely abolishing tumor formation in vivo (Carcinogenesis, 2002; 23(7):1139-1148). To clarify the molecular mechanism behind this effect, we performed 2-DE/MS and DNA microarray analyses in order to compare protein and gene expression patterns of parental HCT116 and PCDH24-expressing HTC116 derivative cells. The data revealed drastic changes in phenotypic ...[more]