Ontology highlight
ABSTRACT:
SUBMITTER: Seregin SS
PROVIDER: S-EPMC5528001 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Seregin Sergey S SS Golovchenko Natasha N Schaf Bryan B Chen Jiachen J Pudlo Nicholas A NA Mitchell Jonathan J Baxter Nielson T NT Zhao Lili L Schloss Patrick D PD Martens Eric C EC Eaton Kathryn A KA Chen Grace Y GY
Cell reports 20170401 4
Dysfunction in host immune responses and pathologic alterations in the gut microbiota, referred to as dysbiosis, can both contribute to the development of inflammatory bowel disease (IBD). However, it remains unclear how specific changes in host immunity or the microbiota cause disease. We previously demonstrated that the loss of the innate immune receptor NLRP6 in mice resulted in impaired production of interleukin-18 (IL-18) and increased susceptibility to epithelial-induced injury. Here, we s ...[more]