Ontology highlight
ABSTRACT:
SUBMITTER: Gunasekera DC
PROVIDER: S-EPMC7566780 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Gunasekera Dilini C DC Ma Jinxia J Vacharathit Vimvara V Shah Palak P Ramakrishnan Amritha A Uprety Priyanka P Shen Zeli Z Sheh Alexander A Brayton Cory F CF Whary Mark T MT Fox James G JG Bream Jay H JH
Mucosal immunology 20200113 3
Mice deficient in the IL-10 pathway are the most widely used models of intestinal immunopathology. IL-17A is strongly implicated in gut disease in mice and humans, but conflicting evidence has drawn IL-17's role in the gut into question. IL-22 regulates antimicrobial and repair activities of intestinal epithelial cells (IECs) and is closely associated with IL-17A responses but it's role in chronic disease is uncertain. We report that IL-22, like IL-17A, is aberrantly expressed in colitic Il10<su ...[more]