Ontology highlight
ABSTRACT:
SUBMITTER: McMillan BJ
PROVIDER: S-EPMC5528166 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Cell reports 20170501 9
The ESCRT-III complex induces outward membrane budding and fission through homotypic polymerization of its core component Shrub/CHMP4B. Shrub activity is regulated by its direct interaction with a protein called Lgd in flies, or CC2D1A or B in humans. Here, we report the structural basis for this interaction and propose a mechanism for regulation of polymer assembly. The isolated third DM14 repeat of Lgd binds Shrub, and an Lgd fragment containing only this DM14 repeat and its C-terminal C2 doma ...[more]