Ontology highlight
ABSTRACT:
SUBMITTER: Yang D
PROVIDER: S-EPMC2593743 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20081109 12
The endosomal sorting complex required for transport (ESCRT) machinery, including ESCRT-III, localizes to the midbody and participates in the membrane-abscission step of cytokinesis. The ESCRT-III protein charged multivesicular body protein 1B (CHMP1B) is required for recruitment of the MIT domain-containing protein spastin, a microtubule-severing enzyme, to the midbody. The 2.5-A structure of the C-terminal tail of CHMP1B with the MIT domain of spastin reveals a specific, high-affinity complex ...[more]