Ontology highlight
ABSTRACT:
SUBMITTER: Singh DR
PROVIDER: S-EPMC5528180 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Singh Deo R DR Ahmed Fozia F Sarabipour Sarvenaz S Hristova Kalina K
Journal of molecular biology 20170523 14
Epithelial cadherin (Ecadherin) is responsible for the intercellular cohesion of epithelial tissues. It forms lateral clusters within adherens cell-cell junctions, but its association state outside these clusters is unknown. Here, we use a quantitative Forster resonance energy transfer (FRET) approach to show that Ecadherin forms constitutive dimers and that these dimers exist independently of the actin cytoskeleton or cytoplasmic proteins. The dimers are stabilized by intermolecular contacts th ...[more]