Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC5530680 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Yuan Ye Y Spate Lee D LD Redel Bethany K BK Tian Yuchen Y Zhou Jie J Prather Randall S RS Roberts R Michael RM
Proceedings of the National Academy of Sciences of the United States of America 20170703 29
Assisted reproductive technologies in all mammals are critically dependent on the quality of the oocytes used to produce embryos. For reasons not fully clear, oocytes matured in vitro tend to be much less competent to become fertilized, advance to the blastocyst stage, and give rise to live young than their in vivo-produced counterparts, particularly if they are derived from immature females. Here we show that a chemically defined maturation medium supplemented with three cytokines (FGF2, LIF, a ...[more]