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Trifluoromethylation of Secondary Nitroalkanes.

ABSTRACT: Using a commercially available Umemoto's reagent, the metal-free trifluoromethylation of nitroalkanes is now possible. This method provides a general, high-yielding synthesis of ?-(trifluoromethyl)nitroalkanes. The quaternary ?-(trifluoromethyl)nitroalkanes obtained from this transformation can be elaborated to a variety of complex nitrogen-containing molecules, including ?-(trifluoromethyl)amines.

SUBMITTER: Gietter-Burch AAS

PROVIDER: S-EPMC5531277 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Trifluoromethylation of Secondary Nitroalkanes.

Gietter-Burch Amber A S AAS Devannah Vijayarajan V Watson Donald A DA

Organic letters 20170523 11

Using a commercially available Umemoto's reagent, the metal-free trifluoromethylation of nitroalkanes is now possible. This method provides a general, high-yielding synthesis of α-(trifluoromethyl)nitroalkanes. The quaternary α-(trifluoromethyl)nitroalkanes obtained from this transformation can be elaborated to a variety of complex nitrogen-containing molecules, including α-(trifluoromethyl)amines. ...[more]

PMID: 28535057

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