Ontology highlight
ABSTRACT:
SUBMITTER: Fang X
PROVIDER: S-EPMC5531406 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Fang Xi X Bogomolovas Julius J Wu Tongbin T Zhang Wei W Liu Canzhao C Veevers Jennifer J Stroud Matthew J MJ Zhang Zhiyuan Z Ma Xiaolong X Mu Yongxin Y Lao Dieu-Hung DH Dalton Nancy D ND Gu Yusu Y Wang Celine C Wang Michael M Liang Yan Y Lange Stephan S Ouyang Kunfu K Peterson Kirk L KL Evans Sylvia M SM Chen Ju J
The Journal of clinical investigation 20170724 8
Defective protein quality control (PQC) systems are implicated in multiple diseases. Molecular chaperones and co-chaperones play a central role in functioning PQC. Constant mechanical and metabolic stress in cardiomyocytes places great demand on the PQC system. Mutation and downregulation of the co-chaperone protein BCL-2-associated athanogene 3 (BAG3) are associated with cardiac myopathy and heart failure, and a BAG3 E455K mutation leads to dilated cardiomyopathy (DCM). However, the role of BAG ...[more]